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Clomipramine, but not imipramine, can target the cingulate cortex and so treat obsession. , 1994). The theory also allows for more general effects. For example, monoamines (serotonin, noradrenaline and dopamine) innervate much of the fear and anxiety systems. As a result, tricyclic drugs, clomipramine, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors all increase monoamine function and so have both anti-anxiety and anti-panic effects. ) Likewise, many of the structures of the anxiety system (right hand side of Fig.