By Ron Brookmeyer (Author), Mitchell H. Gail (Author)
AIDS has seemed in additional than one hundred thirty international locations, and over 100,000 circumstances of AIDS were suggested within the U.S. by myself. a growing number of, the general public should be counting on statisticians to supply solutions in regards to the destiny process this epidemic. This finished paintings confronts the issues which are precise to AIDS learn and unites them below a unmarried conceptual framework. It specializes in tools for the layout and research of epidemiologic reviews, the traditional heritage of AIDS and the transmission of HIV, equipment for monitoring and projecting the process the epidemic, and statistical concerns in healing trials. a few of the equipment of tracking and forecasting this sickness obtain finished remedy. those equipment comprise back-calculation, which the authors built; interpretation of survey info on HIV incidence; mathematical versions for HIV transmission; and methods that mix forms of epidemiological info. a lot of this fabric -- resembling a dialogue of tools for assessing protection of the blood provide, an overview of survey techniques, and techniques to venture pediatric AIDS prevalence -- isn't really on hand in the other paintings.
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Extra info for AIDS Epidemiology: A Quantitative Approach (Monographs in Epidemiology and Biostatistics ; V. 22)
3). Provision must be made for secular trends in the incubation distribution that arose from changes in the definition of AIDS and from the use of treatments capable of retarding the onset of AIDS, particularly after 1987. 3) and to project AIDS incidence. Indeed, back-calculation yields comparatively reliable projections of AIDS incidence, unless sudden changes in the surveillance system or new methods of treatment supervene. The number of persons living with AIDS (AIDS prevalence) and the corresponding AIDS prevalence rate, which is obtained by dividing by the population size, are important indicators of the need for health services.
Such studies could identify factors associated with increased risk of incident seroconversion. 1). 3 we discuss the strengths and weaknesses of these designs and some of the findings from such studies. Studies of the types just mentioned were applied to determining factors affecting risk of infection among homosexual or bisexual men, intravenous drug users (IVDUs), patients with hemophilia, and heterosexuals. In these case-control and cohort studies, there is usually 19 20 AIDS Epidemiology: A Quantitative Approach little information on the precise time or times when exposure to HIV occurred.
This number represents a substantial fraction of the approximately 14,000 patients with hemophilia in the United States (Peterman and Allen, 1989). The risk of infection was related to the type and severity of hemophilia. , 1989). This dose-response relationship between disease severity, which determines the clotting factor requirements, and the chance of infection was also seen for other types of hemophilia. Thirty-one percent of patients with type B hemophilia (factor IX deficiency) were infected, and 14% of patients with other forms of hemophilia were infected.